PreClinical Pathfinder offers a full spectrum of preclinical services utilizing state of the art facilities with highly skilled staff. Pathfinder works in a participative manner with our clients from lead optimization through study design, execution, and reporting. Our process ensures at all times compliance with federal guidelines.

Lead Optimization

Compound failure during the preclinical phase of drug development can be very costly. At Pathfinder, we believe that the rate of failure can be significantly reduced or prevented through optimizing the lead candidate selection process. Our depth of experience in scientific research, knowledge, experience in screening compounds will instill confidence that a successful lead compound is chosen.

Animal Models:

We have available a wide range of animals models including rodent as well as large animals. We have access to a diverse array of genetically modified animals and tumor models for mechanistic and imaging studies including luciferase and fluorescence reporters, and cell specific reporters for a variety of immune cells subtypes, endothelial cells, lymphatics, and other specific tissues of interest. We have a wide range of surgical models suitable for imaging, device implantation, orthopedic applications, cardiovascular endpoints, pulmonary function, and wound healing. We are also capable of developing unique models.

Imaging:

We specialize in quantitative imaging techniques, taking advantage of state of the art imaging facilities including optical imaging of bioluminescent and fluorescence reporters or probes through whole animal imaging systems or intravital micrsocopy, as well as PET, microCT, and MRI. This allows for characterization of cell trafficking, real-time pharmacodynamics, longitudinal evaluation of therapeutic efficacy, and quantification of functional and morphological indicators of response and/or toxicity. Imaging methods are adapted specific to each application to obtain to most relevant and useful information.

Pharmacokinetics/ADME:

PK/ADME screening is a critical phase of lead optimization, ensuring the candidate drug is bioavailable
and getting to the target of interest.

Toxicology:

Pathfinder provides both Non-GLP and GLP toxicology services. These include, but not limited to:

  • In vitro and in vivo studies
  • Pilot studies
  • Dose range finding studies
  • Maximum tolerated dose finding studies
  • Sub-chronic and chronic toxicology
  • Repeat dose studies
  • Carcinogenicity studies
  • Developmental toxicology
  • Reproductive toxicology

Pharmacology:

Safety pharmacology studies are essential and required when conducting a program for IND application. Pathfinder offers a vast array of safety tests to determine/monitor effects of the drug candidate to the cardiovascular, respiratory, and central nervous systems. Our experienced team will design customized studies to meet your goals and regulatory requirements.

Devices:

Critical to medical devices is the identification and evaluation of materials that will be used in humans. Pathfinder utilizes its research, experience, and expertise to design customized testing programs to determine biocompatibility and safety for medical devices. All studies are designed and executed to meet federal regulatory requirements.

Species:

At Pathfinder, we work with the following species:

  • Rodents – rats/mice
  • Dogs
  • Rabbits
  • Non-Human Primates
  • Pigs

Routes of Administration:

  • Oral
  • Intramuscular
  • Intravenous
  • Subcutaneous
  • Sublingual
  • Dermal
  • Ocular